Takahiro Domoto Selected Research

Glycogen Synthase Kinases

12/2020	Glycogen synthase kinase-3β participates in acquired resistance to gemcitabine in pancreatic cancer.
2/2020	Glycogen synthase kinase 3β as a potential therapeutic target in synovial sarcoma and fibrosarcoma.
1/2020	Potential therapeutic effect of targeting glycogen synthase kinase 3β in esophageal squamous cell carcinoma.
1/2020	Glycogen Synthase Kinase 3β in Cancer Biology and Treatment.
3/2018	Colorectal cancer cells require glycogen synthase kinase-3β for sustaining mitosis via translocated promoter region (TPR)-dynein interaction.
10/2016	Glycogen synthase kinase-3β is a pivotal mediator of cancer invasion and resistance to therapy.
2/2015	Glycogen synthase kinase 3β sustains invasion of glioblastoma via the focal adhesion kinase, Rac1, and c-Jun N-terminal kinase-mediated pathway.

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Takahiro Domoto Research Topics

Disease

13	Neoplasms (Cancer) 01/2022 - 11/2010
4	Fibrosarcoma 02/2020 - 11/2010
4	Glioblastoma (Glioblastoma Multiforme) 11/2019 - 02/2015
3	Squamous Cell Carcinoma (Epidermoid Carcinoma) 12/2014 - 11/2010
2	Colorectal Neoplasms (Colorectal Cancer) 01/2022 - 03/2018
2	Pancreatic Neoplasms (Pancreatic Cancer) 12/2020 - 10/2016
2	Sarcoma (Soft Tissue Sarcoma) 02/2020 - 11/2016
2	Glioma (Gliomas) 11/2019 - 01/2016
1	Synovial Sarcoma (Synovioma) 02/2020
1	Esophageal Squamous Cell Carcinoma 01/2020
1	Gastrointestinal Neoplasms (Gastrointestinal Cancer) 01/2020
1	Osteosarcoma (Osteogenic Sarcoma) 11/2016
1	Brain Neoplasms (Brain Tumor) 01/2016
1	Neoplasm Metastasis (Metastasis) 11/2012
1	Breast Neoplasms (Breast Cancer) 11/2011

Drug/Important Bio-Agent (IBA)

7	Glycogen Synthase KinasesIBA 12/2020 - 02/2015
5	Glycogen Synthase (Synthase I)IBA 12/2020 - 02/2015
5	Matrix Metalloproteinase 14 (MT1-MMP)IBA 01/2016 - 11/2010
4	Biological ProductsIBA 01/2022 - 10/2016
3	Cyclin D1IBA 12/2020 - 01/2020
3	CollagenIBA 02/2020 - 11/2010
2	Proteins (Proteins, Gene)FDA Link 01/2022 - 03/2012
2	Therapeutic UsesIBA 01/2020 - 01/2020
2	Temozolomide (Temodar)FDA LinkGeneric 11/2019 - 02/2015
2	Fibronectins (Fibronectin)IBA 07/2013 - 11/2011
1	Pharmaceutical PreparationsIBA 01/2022
1	Nuclear Pore Complex Proteins (Nucleoporins)IBA 01/2022
1	E2F1 Transcription FactorIBA 12/2020
1	Retinoblastoma ProteinIBA 12/2020
1	Gemcitabine FDA Link 12/2020
1	thymidine kinase 1IBA 12/2020
1	Thymidylate SynthaseIBA 12/2020
1	Transcription Factors (Transcription Factor)IBA 12/2020
1	Tumor Suppressor Proteins (Proteins, Tumor Suppressor)IBA 12/2020
1	Cyclin B1IBA 01/2020
1	RNA (Ribonucleic Acid)IBA 01/2020
1	Tyrosine (L-Tyrosine)FDA Link 01/2020
1	Oncogene Proteins (Oncogene Protein)IBA 01/2020
1	Cyclin-Dependent Kinases (cdk Proteins)IBA 01/2020
1	kenpaulloneIBA 11/2019
1	Dyneins (Dynein)IBA 03/2018
1	CateninsIBA 11/2016
1	Phosphotransferases (Kinase)IBA 11/2016
1	NF-kappa B (NF-kB)IBA 01/2016
1	JNK Mitogen-Activated Protein KinasesIBA 02/2015
1	Focal Adhesion Protein-Tyrosine KinasesIBA 02/2015
1	VinculinIBA 12/2014
1	matriptaseIBA 03/2012
1	Peptide Hydrolases (Proteases)FDA Link 03/2012
1	Dexamethasone (Maxidex)FDA LinkGeneric 11/2011
1	Small Interfering RNA (siRNA)IBA 11/2010

Therapy/Procedure

6	Therapeutics 01/2020 - 02/2015
2	Drug Therapy (Chemotherapy) 12/2020 - 10/2016
1	Radiotherapy 10/2016